It was founded in 1844.
Built in 1844 as a district church for part of the township of Macclesfield (previously served by Macclesfield: St. Michael & All Angels). The boundaries of "The District of Saint Paul, Macclesfield" were described in the London Gazette on 10 July 1844:
"All that part of the chapelry of Macclesfield, in the parish of Prestbury, and in the said county and diocese of Chester, bounded on the north, by the township of Hurdsfield, on the west, by the river Bollin, on the east, by the township of Rainow, and on the south, by an imaginary line extending towards the south-west, from the western boundary of such last-mentioned township, along the middle of the turnpike road from Macclesfield to Buxton, to a point in the centre of the space where the said road, the old road to Buxton, and the road to Hurdsfield meet, and thence in a straight direction to the north-east corner of the New Town Reservoir, and thence westward, along the northern side of such reservoir and in a straight direction towards the south-west, from the extreme north-western corner thereof, to a point on the eastern side of Knight's Reservoir, opposite to the centre thereof, and thence towards the south-west, along the same side of such last-mentioned reservoir, and westward, along a certain brook running from the same reservoir, as far as the said river Bollin"
C = Christenings (Baptisms) ; M = Marriages ; B = Burials ; BTs = Bishop's Transcripts